A biologic drug for the treatment of chronic obstructive pulmonary disease

Image credit – Straits Times, 24 April 2022

A research team led by Associate Professor GE Ruowen from the Department of Biological Sciences, National University of Singapore (NUS) recently revealed that ISM1 is critical for restraining inflammation in a healthy lung by selectively eliminating the pro-inflammatory alveolar macrophages. ISM1 achieved this by targeting the GRP78 signalling receptor (csGRP78) present on the cell surface of the alveolar macrophages. 

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