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CBIS Events

CBIS Seminar: Data heterogeneity in single particle imaging with X-ray free electron lasers by Shen Zhou

Friday, 19 MAR 2021 | X-ray free-electron laser (XFEL) is an emerging technology that may overcome the damage-limited resolution in single-particle imaging (SPI) with electron cryomicroscopy (cryoEM).
CBIS Seminar: Structure basis for RNA-guided DNA targeting and degradation in Type 1 CRISPR-Cas system by Luo Min

Friday, 5 MAR 2021 | CRISPR-Cas systems are RNA-based adaptive immune systems found in prokaryotes, and nowadays are widely employed for gene-editing purposes. Type 1 CRISPR-Cas, a most prevalent CRISPR-Cas system, first employ a crRNA-displaying Cascade for dsDNA target searching to form a full R-loop structure, and subsequently utilise a nuclease-helicase fusion enzyme Cas3 for the degradation process.
CBIS Seminar: Investigation of epidermal growth factor receptor (EGFR) organisation and dynamics on plasma membrane of live cells using fluorescence methods by Harikrushnan Balasubramanian

Friday, 26 FEB 2021 | The epidermal growth factor receptor (EGFR), a transmembrane receptor tyrosine kinase, is a crucial regulator of proliferation and survival, and its mutations and dysregulated signalling have been implicated in many cancers. However, a clear understanding of its oligomerization state, dynamics, and interactions have been elusive.
CBIS Seminar: Introduction to the CBIS IT infrastructure by Al Davis

Friday, 19 FEB 2021 | The first of a multi-session workshop on CBIS IT infrastructure, software applications, basic programming, application performance tuning, and data processing methods.
Virtual Biology Colloquium: Stem Cells in Crypt-like Structures Lining the Base of the Zebrafish Intestine by Paul Matsudaira

Friday, 15 JAN 2021 | In the mammalian intestine, stem cells located in basal crypts, replicated and translocation along the villus where they die and are shed from the tips. We propose that the villus/crypt architecture of our intestine evolved from further differentiation of these flat crypt-like structure into the elongated crypt.
CBIS Seminar: Machine learning advances in cryo-EM and cryo-ET image processing by Tristan Bepler

Friday, 18 DEC 2020 | Cryo-electron microscopy can resolve protein structures in near native state at atomic resolution. New methods for discovering continuous states in cryo-EM data are needed.
CBIS Seminar: Structural basis of drug recognition, inhibitor blockage, and asymmetrical conformational changes of human P-glycoprotein by Luo Min

Friday, 11 DEC 2020 | P-glycoprotein is one of the most prominent human multidrug transporters involved in chemotherapy resistance, yet despite decades of investigations remains poorly defined.
CBIS Seminar: Shedding light on chromatin organization and dynamics in space and time by Ziqing (Winston) Zhao

Friday, 4 DEC 2020 | The organisation and dynamics of chromatin and chromatin-protein interactions in space and time often play crucial roles in regulating the outcomes of diverse intracellular processes that modulate the human genome.
CBIS Seminar: Flagellar length regulation by Cynthia He

Friday, 20 NOV 2020 | Current understanding of flagellum length regulation focuses on a few model organisms with flagella of uniform length. The He lab proposes a min-max model that could account for the vast flagellar length range observed for asynchronous L. Pyrrhocoris, which may also apply to other flagellated organisms.
CBIS Seminar: Live imaging of bone cell interactions in a fish model for human skeletal disorders by Tan Wen Hui

Friday, 13 NOV 2020 | Small fishes such as medaka and zebrafish are popular models in biological research.The Winkler lab uses medaka as a model for studying human bone disorders.
CBIS Seminar: Exploration of eukaryotic nuclei in situ with Cryo-ET by Lu Gan

Friday, 6 NOV 2020 | The eukaryotic cell nucleus is a poorly understood organelle, even though it hosts essential processes like transcription and replication. The Lu lab has taken advantage of advances in sample preparation and image-processing workflows to analyse macromolecular complexes with the cell nuclei.
CBIS Seminar: Using statistical learning and the physics of image formation to evolve exploratory microscopy by Duane Loh

Friday, 30 OCT 2020 | The evolution of human vision is a fascinating interaction between our eyes and brains. At the very beginning, so the story goes, variations of primitive eyes receive input that is interpreted by simple yet plastic neural networks that in turn trigger responses.

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