About CBIS

The NUS Centre for Bioimaging Sciences

Founded by faculty from Biological Sciences, Chemistry, and Physics, the Centre for BioImaging Sciences’ (CBIS) research is focused on the science and application of biological imaging by light and electron microscopy and the development of computational and microscopy-based methods and technologies. With an interdisciplinary emphasis on the mechanism of biological processes at the molecular, cell, and tissue levels, CBIS complements the development of advanced light microscopy technologies in Singapore.

CBIS

CBIS news

30 June 2024 – winner of CBIS microscopy image competition

Zhang Shiyu
(PI: Assoc Prof Liou Yih-Cherng, NUS Department of Biological Sciences)

Tracking the newborn centriole in synchronized HeLa cells: HeLa cells were synchronized at G1/S and then released. Centriole growth was monitored every 240 minutes for 12 hours until the cells reached G2/M. Ultra-expanded and stained for acetylated α-tubulin (mpl-Inferno), both longitudinal (left 4 panels) and orthogonal (right 4 panels) views reveal the dynamic lengthening of newborn centrioles. Row 1: 0 minutes post-release. Row 2: 240 minutes post-release. Row 3: 480 minutes post-release. Row 4: 720 minutes post-release. Scale bar, 0.5 μm

Imaged with ZEISS LSM 900 with Airyscan 2, CBIS Light Microscopy Core

April 2024 – CBIS microscopy image competition

Submission deadline 31 May 2024 · terms and conditions

August 2023 – New in-situ cryotomography technique discerns nanometer-scale structures in chromatin with broad applications in cell biology.

Principal investigator: Lu Gan | lab website | read the paper

September 2022 – By knowing the physics of electron-matter interactions, a single 2D transmission electron micrograph can now be used to reconstruct 3D structures at nanometer resolution.

Principal investigator: Duane Loh | lab website | read the paper

©Deepan Balakrishnan