800 MHz NMR (Bruker Avance Neo), DBS/NUS
Our 800 MHz Avance Neo Spectrometer is the highest field and most modern instrument in Singapore and Asean. It is equipped with a Bruker TXI cryoprobe that provides about a 4:1 Signal-to-Noise improvement over conventional probes (S/N ration for 1H is 8800:1).
It is highly suited for metabolomic studies, the study of complex biomolecules like proteins and nucleic acids, Fragment-based screening for new drug discovery and routine 1H and 13C NMR experiments on small molecules. Our NMR facility serves DBS and NUS research community and external research institutes with flexible collaborations.
Spectrometer Information
800 MHz Avance Neo Spectrometer located at S8-01-02, Science Drive 3 (S117543) Uses Topspin 4.1 software on a Linux Centos 7 Workstation
Available Probes
- usually Equipped with a 5 mm Bruker 1H / 13C / 15N / 2H Bruker CPTXI Cryoprobe Ideal for study of metabolomics and complex biomolecules;
Exceptional sensitivity for 1H direct detection and 13C / 15N indirect detection; Automatic tuning and matching;
Temperature range 0 degree – 50 degree, higher stability (<0.1 degree);
-
5 mm Bruker TXI Z-Grad HCN liquids probe for 800 MHz;
-
5 mm Bruker BBO Z-Grad liquid probe for 800 MHz;
Available Service
-
Bio-marker identification for metabolomics and Elucidation of small molecules;
-
Structure and dynamics study for biomolecules (proteins, nucleic acids & polysaccharide);
-
quantification analysis for industry products;
-
FBS drug discovery;
Charge rates (minimum 1 hour)
$50.00 per hour for NUS users;
$100.00 per hour for external academic users;
$200.00 per hour for company /industry users;
Examples of Spectrometer Usage
Protein structure and conformational dynamics determined by our NMR spectrometer
https://blog.nus.edu.sg/yang/publications/
https://www.dbs.nus.edu.sg/staffs/mok-yu-keung-henry/?cid=59
https://www.dbs.nus.edu.sg/staffs/song-jianxing/?cid=59
Contact information: Dr. Fan Jingsong | Tel: 65164406 | Hp: 87773602 | Email: dbsfjs@nus.edu.sg
