---

Education

Ph.D., Infection and Immunity, Helmholtz Institute for RNA-based Infection Research (HIRI), Germany (2022)

M.Sc., Microbiology, Shandong University, China (2015)

B.Sc. Biotechnology, Henan Polytechnic University, China (2012)

Professional Experience

Assistant Professor, Presidential Young Professorship, National University of Singapore (2024 –  present)

Postdoc., Helmholtz Institute for RNA-based Infection Research (HIRI), Germany (2022 – 2024)

Research Engineer, Ngee Ann Polytechnic, Singapore (2016 – 2018)

Research Assistant, Shandong University, China (2015 – 2016)

Research Interest

Discovery, engineering, and design of CRISPR and novel bacterial defense systems with the aim of developing innovative platforms for disease diagnosis and treatment.

Current Research Projects

1. Develop a sensitive and high-throughput RNA detection platform

2. Develop a precise and high efficient knock-in platform in eukaryotic cells

3. Develop a precise and non-cytotoxic RNA knock-down platform

4. Develop a long-range genome knock-out platform

5. Develop a spatial RNA recording platform

Selected Publications

1. Jiao, C., Peeck, N.L., Yu, J., Ghaem Maghami, M., Kono, S., Collias, D., Martinez Diaz, S.L., Larose, R. and Beisel, C.L., 2024. TracrRNA reprogramming enables direct PAM-independent detection of RNA with diverse DNA-targeting Cas12 nucleases. Nature Communications, 15(1), p.5909.

2. Jiao, C., Reckstadt, C., König, F., Homberger, C., Yu, J., Vogel, J., Westermann, A.J., Sharma, C.M. and Beisel, C.L., 2023. RNA recording in single bacterial cells using reprogrammed tracrRNAs. Nature biotechnology, 41(8), pp.1107-1116.

3. Jiao, C. and Beisel, C.L., 2022. Reprogramming TracrRNAs for Multiplexed RNA Detection. In Riboregulator Design and Analysis (pp. 217-235). New York, NY: Springer US.

4. Jiao, C., Sharma, S., Dugar, G., Peeck, N.L., Bischler, T., Wimmer, F., Yu, Y., Barquist, L., Schoen, C., Kurzai, O. and Sharma, C.M., 2021. Noncanonical crRNAs derived from host transcripts enable multiplexable RNA detection by Cas9. Science, 372(6545), pp.941-948.

5. Hou, J.#, Jiao, C.#, Peng, B., Shen, Y. and Bao, X., 2016. Mutation of a regulator Ask10p improves xylose isomerase activity through up-regulation of molecular chaperones in Saccharomyces cerevisiae. Metabolic Engineering, 38, pp.241-250. (#, co-first author)

6. Hou, J., Shen, Y., Jiao, C., Ge, R., Zhang, X. and Bao, X., 2016. Characterization and evolution of xylose isomerase screened from the bovine rumen metagenome in Saccharomyces cerevisiae. Journal of bioscience and bioengineering, 121(2), pp.160-165.