![LIM XIN XIANG](https://www.dbs.nus.edu.sg/wp-content/uploads/sites/7/2021/08/Lim-Xin-Xiang_Passport-Photo.jpg)
LIM XIN XIANG
Lecturer
Contact information:
Department of Biological Sciences
National University of Singapore
14 Science Drive 4
Singapore 117543
6516 7722
xinxiang@nus.edu.sg
Academic Qualifications:
Doctor of Philosophy, National University of Singapore
Bachelor of Science (Hons 1st Class), National University of Singapore
Teaching Areas
FSC4201 – Articulating Probability and Statistics in Court
FSC4202 – Forensic Human Identification
FSC4204 – Criminalistics: Evidence and Proof
FSC4205 – Criminalistics: Forgery Exposé with Forensic Science
FSC5202 – Forensic Defence Science
FSC5204 – Forensic Psychiatry & Psychology
FSC5199 – Research Project in Forensic Science
LSM1111 – Biological Challenges and Opportunities for Humankind
LSM2191 – Laboratory Techniques in Life Sciences
LSM4299 – Applied Projects in Life Sciences
Research Interest
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Forensic dactyloscopy
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Forensic trace analysis
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Forensic genetics
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Forensic proteomics
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Molecular dynamics of viruses & antibody interactions
Selected publications
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Xin-Xiang Lim, Bo Shu, Shuijun Zhang, Aaron W.L. Tan, Thaim-Seng Ng, Xin-Ni Lim, Shyn-Yun Valerie Chew, Jian Shi, Gavin R. Screaton, Shee-Mei Lok, Ganesh S. Anand (2021). Human antibody C10 neutralizes by diminishing Zika but enhancing dengue virus dynamics. Cell. https://doi.org/10.1016/j.cell.2021.11.009.
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Xin-Xiang Lim, Arun Chandramohan, Xin Ying Elisa Lim, Nirmalya Bag, Kamal Kant Sharma, Melissa Wirawan, Thorsten Wohland, Shee-Mei Lok & Ganesh S. Anand (2017). Conformational changes in intact dengue virus reveal serotype-specific expansion. Nat. Commun 8, 14339 (2017) doi: 10.1038/ncomms14339
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Xin-Xiang Lim, Arun Chandramohan, Xin Ying Elisa Lim, James E. Crowe, Jr., Shee-Mei Lok & Ganesh S. Anand (2017). Epitope and paratope mapping reveals temperature-dependent alterations in dengue-antibody interface. Structure, DOI: http://dx.doi.org/10.1016/j.str.2017.07.007
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Priscilla Boon, Wuan Geok Saw, Xin-Xiang Lim, Palur Venkata Raghuvamsi, Roland G. Huber, Jan K. Marzinek, Daniel A. Holdbrook, Ganesh S. Anand, Gerhard Grüber, Peter J. Bond (2018). Partial Intrinsic Disorder Governs the Dengue Capsid Protein Conformational Ensemble. ACS Chem Biol. 2018, 13, 1621 – 1630.
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Ter Yong Tan, Guntur Fibriansah, Victor Kostyuchenko, Thiam-Seng Ng, Xin-Xiang Lim, ShuiJun Zhang, Xin-Ni Lim, Jiaqi Wang, Jian Shi, Marc Morais, Davide Corti, Shee-Mei Lok. (2020) Capsid protein structure in Zika virus reveals the flavivirus assembly process. Nat Commun 11, 895 (2020). DOI: https://doi.org/10.1038/s41467-020-14647-9
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Melissa Wirawan, Guntur Fibriansah, Jan K. Marzinek, Xin-Xiang Lim, Thiam-Seng Ng, Adelene Y. L. Sim, Qian Zhang, Victor A. Kostyuchenko, Jian Shi, Scott A. Smith, Chandra S Verma, Ganesh Anand, James E. Crowe Jr., Peter J. Bond & Shee-Mei Lok (2018). Mechanism of enhanced immature dengue virus attachment to endosomal membrane induced by prM antibody. Structure, DOI:https://doi.org/10.1016/j.str.2018.10.009
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Kamal Kant Sharma, Xin-Xiang Lim, Sarala Neomi Tantirimudalige, Anjali Gupta, Jan K. Marzinek, Xin Ying Elisa Lim, Peter J. Bond, Ganesh S. Anand, Thorsten Wohland (2019). Infectivity of dengue virus serotypes 1 and 2 is correlated to E protein intrinsic dynamics but not to envelope conformations. Structure. doi: 10.1016/j.str.2018.12.006. Epub 2019 Jan 24.
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Ranita Ramesh, Xin-Xiang Lim, Palur Venkata Raghuvamsi, Wu Chao, Wong Sek Man, Ganesh Srinivasan Anand. (2018) Uncovering metastability and disassembly hotspots in whole viral particles. Progress in Biophysics and Molecular Biology. pii: S0079-6107(18)30184-6. doi: 10.1016/j.pbiomolbio.2018.12.006.
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Krishnamurthy, S, Moorthy, BS, Lim Xin Xiang, Lim Xin Shan, Bharatham, K, Tulsian, N, Mihalek, I and Ganesh S. Anand (2014). Active Site Coupling in PDE:PKA Complexes Promotes Resetting of Mammalian cAMP Signaling. Biophysical J. Sep 16;107(6):1426-40. doi: 10.1016/j.bpj.2014.07.050