![SEBASTIAN MAURER-STROH](https://www.dbs.nus.edu.sg/wp-content/uploads/sites/7/2020/02/sebastian.jpg)
SEBASTIAN MAURER-STROH
Adjunct Professor
Contact Information:
Executive Director, Bioinformatics Institute (BII)A*STAR, 30 Biopolis Street, #07-01 Matrix, Singapore 138671
Link to Lab Webpage https://www.a-star.edu.sg/bii/research/bsfd/psa
Link to personal page https://www.a-star.edu.sg/bii/research/bsfd/psa
Link to CV (pdf format) https://www.a-star.edu.sg/bii/research/bsfd/psa
6478 8377
sebastianms@bii.a-star.edu.sg
Research Areas
Sequence analysis, Protein structure, Protein function, Phylogeny, Evolution, Mutation, Enzymes, Allergens, Virus
Research Interests
My research interest is in computational protein sequence and structure analysis to predict various aspects of molecular and cellular functions (enzymatic activities, posttranslational modifications, cleavage, translocation signals, 3D structures, effects of mutations, phylogenetic relationships, cellular pathways etc.) for discovering the molecular mechanisms of biological and clinical phenotypes and experimental validation together with collaborators. Our repertoire of computational analysis methods is applicable and useful in multiple research areas but our main focus currently is on infectious diseases, human mutations, allergy and enzyme function prediction.
Selected Publications
>188 publications, h-index 64
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AllerCatPro 2.0: a web server for predicting protein allergenicity potential Nguyen MN, Krutz NL, Limviphuvadh V, Lopata AL, Gerberick GF, Maurer-Stroh S. Nucleic Acids Res. 2022 May 30:gkac446. doi: 10.1093/nar/gkac446. Online ahead of print.
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GISAID’s Role in Pandemic Response Khare S, Gurry C, Freitas L, Schultz MB, Bach G, Diallo A, Akite N, Ho J, Lee RT, Yeo W, Curation Team GC, Maurer-Stroh S. China CDC Wkly. 2021 Dec 3;3(49):1049-1051. doi: 10.46234/ccdcw2021.255.
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SARS-CoV-2 Variants of Interest and Concern naming scheme conducive for global discourse Konings F, Perkins MD, Kuhn JH, Pallen MJ, Alm EJ, Archer BN, Barakat A, Bedford T, Bhiman JN, Caly L, Carter LL, Cullinane A, de Oliveira T, Druce J, El Masry I, Evans R, Gao GF, Gorbalenya AE, Hamblion E, Herring BL, Hodcroft E, Holmes EC, Kakkar M, Khare S, Koopmans MPG, Korber B, Leite J, MacCannell D, Marklewitz M, Maurer-Stroh S, Rico JAM, Munster VJ, Neher R, Munnink BO, Pavlin BI, Peiris M, Poon L, Pybus O, Rambaut A, Resende P, Subissi L, Thiel V, Tong S, van der Werf S, von Gottberg A, Ziebuhr J, Van Kerkhove MD. Nat Microbiol. 2021 Jul;6(7):821-823. doi: 10.1038/s41564-021-00932-w.
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Loss of C2orf69 defines a fatal autoinflammatory syndrome in humans and zebrafish that evokes a glycogen-storage-associated mitochondriopathy Wong HH, Seet SH, Maier M, Gurel A, Traspas RM, Lee C, Zhang S, Talim B, Loh AYT, Chia CY, Teoh TS, Sng D, Rensvold J, Unal S, Shishkova E, Cepni E, Nathan FM, Sirota FL, Liang C, Yarali N, Simsek-Kiper PO, Mitani T, Ceylaner S, Arman-Bilir O, Mbarek H, Gumruk F, Efthymiou S, Uğurlu Çi Men D, Georgiadou D, Sotiropoulou K, Houlden H, Paul F, Pehlivan D, Lainé C, Chai G, Ali NA, Choo SC, Keng SS, Boisson B, Yılmaz E, Xue S, Coon JJ, Ly TTN, Gilani N, Hasbini D, Kayserili H, Zaki MS, Isfort RJ, Ordonez N, Tripolszki K, Bauer P, Rezaei N, Seyedpour S, Khotaei GT, Bascom CC, Maroofian R, Chaabouni M, Alsubhi A, Eyaid W, Işıkay S, Gleeson JG, Lupski JR, Casanova JL, Pagliarini DJ, Akarsu NA, Maurer-Stroh S, Cetinkaya A, Bertoli-Avella A, Mathuru AS, Ho L, Bard FA, Reversade B. Am J Hum Genet. 2021 Jul 1;108(7):1301-1317. doi: 10.1016/j.ajhg.2021.05.003. Epub 2021 May 25.
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Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia Asarnow D, Wang B, Lee WH, Hu Y, Huang CW, Faust B, Ng PML, Ngoh EZX, Bohn M, Bulkley D, Pizzorno A, Ary B, Tan HC, Lee CY, Minhat RA, Terrier O, Soh MK, Teo FJ, Yeap YYC, Seah SGK, Chan CEZ, Connelly E, Young NJ, Maurer-Stroh S, Renia L, Hanson BJ, Rosa-Calatrava M, Manglik A, Cheng Y, Craik CS, Wang CI. Cell. 2021 Jun 10;184(12):3192-3204.e16. doi: 10.1016/j.cell.2021.04.033. Epub 2021 Apr 24.
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Association of SARS-CoV-2 clades with clinical, inflammatory and virologic outcomes: An observational study Young BE, Wei WE, Fong SW, Mak TM, Anderson DE, Chan YH, Pung R, Heng CS, Ang LW, Zheng AKE, Lee B, Kalimuddin S, Pada S, Tambyah PA, Parthasarathy P, Tan SY, Sun L, Smith GJ, Lin RTP, Leo YS, Renia L, Wang LF, Ng LF, Maurer-Stroh S, Lye DC, Lee VJ. EBioMedicine. 2021 Apr;66:103319. doi: 10.1016/j.ebiom.2021.103319. Epub 2021 Apr 8.
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How the lessons of previous epidemics helped successful countries fight covid-19 Chua AQ, Al Knawy B, Grant B, Legido-Quigley H, Lee WC, Leung GM, Looi MK, Maurer-Stroh S. BMJ. 2021 Mar 11;372:n486. doi: 10.1136/bmj.n486.
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Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study Young BE, Fong SW, Chan YH, Mak TM, Ang LW, Anderson DE, Lee CY, Amrun SN, Lee B, Goh YS, Su YCF, Wei WE, Kalimuddin S, Chai LYA, Pada S, Tan SY, Sun L, Parthasarathy P, Chen YYC, Barkham T, Lin RTP, Maurer-Stroh S, Leo YS, Wang LF, Renia L, Lee VJ, Smith GJD, Lye DC, Ng LFP. Lancet. 2020 Aug 29;396(10251):603-611. doi: 10.1016/S0140-6736(20)31757-8. Epub 2020 Aug 18.
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Investigation of three clusters of COVID-19 in Singapore: implications for surveillance and response measures Pung R, Chiew CJ, Young BE, Chin S, Chen MI, Clapham HE, Cook AR, Maurer-Stroh S, Toh MPHS, Poh C, Low M, Lum J, Koh VTJ, Mak TM, Cui L, Lin RVTP, Heng D, Leo YS, Lye DC, Lee VJM; Singapore 2019 Novel Coronavirus Outbreak Research Team. Lancet. 2020 Mar 28;395(10229):1039-1046. doi: 10.1016/S0140-6736(20)30528-6. Epub 2020 Mar 17.
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Early transmission patterns of coronavirus disease 2019 (COVID-19) in travellers from Wuhan to Thailand, January 2020 Okada P, Buathong R, Phuygun S, Thanadachakul T, Parnmen S, Wongboot W, Waicharoen S, Wacharapluesadee S, Uttayamakul S, Vachiraphan A, Chittaganpitch M, Mekha N, Janejai N, Iamsirithaworn S, Lee RT, Maurer-Stroh S. Euro Surveill. 2020 Feb;25(8):2000097. doi: 10.2807/1560-7917.ES.2020.25.8.2000097.
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Large-Scale Whole-Genome Sequencing of Three Diverse Asian Populations in Singapore Wu D, Dou J, Chai X, Bellis C, Wilm A, Shih CC, Soon WWJ, Bertin N, Lin CB, Khor CC, DeGiorgio M, Cheng S, Bao L, Karnani N, Hwang WYK, Davila S, Tan P, Shabbir A, Moh A, Tan EK, Foo JN, Goh LL, Leong KP, Foo RSY, Lam CSP, Richards AM, Cheng CY, Aung T, Wong TY, Ng HH; SG10K Consortium, Liu J, Wang C. Cell. 2019 Oct 17;179(3):736-749.e15. doi: 10.1016/j.cell.2019.09.019.
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Individual immune selection pressure has limited impact on seasonal influenza virus evolution Han AX, Maurer-Stroh S, Russell CA. Nat Ecol Evol. 2019 Feb;3(2):302-311. doi: 10.1038/s41559-018-0741-x. Epub 2018 Dec 3.
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Outbreak of Zika virus infection in Singapore: an epidemiological, entomological, virological, and clinical analysis Singapore Zika Study Group. Lancet Infect Dis. 2017 Aug;17(8):813-821. doi: 10.1016/S1473-3099(17)30249-9. Epub 2017 May 17.
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Viral factors in influenza pandemic risk assessment Lipsitch M, Barclay W, Raman R, Russell CJ, Belser JA, Cobey S, Kasson PM, Lloyd-Smith JO, Maurer-Stroh S, Riley S, Beauchemin CA, Bedford T, Friedrich TC, Handel A, Herfst S, Murcia PR, Roche B, Wilke CO, Russell CA. Elife. 2016 Nov 11;5:e18491. doi: 10.7554/eLife.18491.
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South-east Asian Zika virus strain linked to cluster of cases in Singapore, August 2016 Maurer-Stroh S, Mak TM, Ng YK, Phuah SP, Huber RG, Marzinek JK, Holdbrook DA, Lee RT, Cui L, Lin RT. Euro Surveill. 2016 Sep 22;21(38):30347. doi: 10.2807/1560-7917.ES.2016.21.38.30347.
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Severe Pediatric Adenovirus 7 Disease in Singapore Linked to Recent Outbreaks across Asia Ng OT, Thoon KC, Chua HY, Tan NW, Chong CY, Tee NW, Lin RT, Cui L, Venkatachalam I, Tambyah PA, Chew J, Fong RK, Oh HM, Krishnan PU, Lee VJ, Tan BH, Ng SH, Ting PJ, Maurer-Stroh S, Gunalan V, Khong WX. Emerg Infect Dis. 2015 Jul;21(7):1192-6. doi: 10.3201/eid2107.141443.
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Conservancy of mAb Epitopes in Ebolavirus Glycoproteins of Previous and 2014 Outbreaks Ponomarenko J, Vaughan K, Sette A, Maurer-Stroh S. PLoS Curr. 2014 Nov 3;6:ecurrents.outbreaks.f1a7028a13ce1c5f0bdbb4b0cc0b919b. doi: 10.1371/currents.outbreaks.f1a7028a13ce1c5f0bdbb4b0cc0b919b.
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Potential human adaptation mutation of influenza A(H5N1) virus, Canada Maurer-Stroh S, Li Y, Bastien N, Gunalan V, Lee RT, Eisenhaber F, Booth TF. Emerg Infect Dis. 2014 Sep;20(9):1580-2. doi: 10.3201/eid2009.140240.
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Exploring the sequence determinants of amyloid structure using position-specific scoring matrices Maurer-Stroh S, Debulpaep M, Kuemmerer N, Lopez de la Paz M, Martins IC, Reumers J, Morris KL, Copland A, Serpell L, Serrano L, Schymkowitz JW, Rousseau F. Nat Methods. 2010 Mar;7(3):237-42. doi: 10.1038/nmeth.1432. Epub 2010 Feb 14.
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The Tudor domain ‘Royal Family’: Tudor, plant Agenet, Chromo, PWWP and MBT domains Maurer-Stroh S, Dickens NJ, Hughes-Davies L, Kouzarides T, Eisenhaber F, Ponting CP. Trends Biochem Sci. 2003 Feb;28(2):69-74. doi: 10.1016/S0968-0004(03)00004-5.