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Research Areas

Stem cells, Organoids, Cardiovascular diseases, Neuroscience, Metabolic disorders.s

Research Interests

My research aims to understand the underlying molecular and cellular mechanisms that underpin disease progression of the human heart and brain, and to develop novel screening platform (2D and 3D) for the evaluation of potential therapeutic intervention. Recapitulation of the in vivo cellular microenvironment is important to provide a more biologically relevant surrogate to predict the response of the organism. Our approach involves adopting new technologies in our research to discover key fundamental knowledge in these fields, as well as to apply and translate research findings, both in clinic and industries.

Selected Publications

1. Lim GS, Hor JH, Ho NRY, Wong CY, Ng SY, Soh BS*, Shao H*. Microhexagon gradient array directs spatial diversification of spinal motor neurons. Theranostics. 2019 Jan 1;9(2):311-323. doi: 10.7150/thno.29755. (*Co-corresponding author).

2. Fan Y, Ho XB, Pang JKS, Pek MQN, Hor JH, Ng SY*, Soh BS*.Wnt/β-catenin mediated signaling re-activates proliferation of matured cardiomyocytes.  Stem Cell Res Ther. 2018 Dec 7;9(1):338. doi: 10.1186/s13287-018-1086-8. (*Co-corresponding author).

3. Li Y, Kang XJ, Pang JKS, Soh BS, Yu Y, Fan Y. Human Germline Editing: Insights to future clinical treatment of diseases. Protein Cell. 2018 Nov 14. doi: 10.1007/s13238-018-0594-8.

4. Hor JH, Soh ESY, Tan LY, Lim VJW, Santosa MM, Winanto W, Ho XB, Fan Y, Soh BS*, Ng SY*. Cell cycle inhibitors protect motor neurons in an organoid model of sponal muscular atrophy. Cell Death and Disease (2018)9:1100 DOI 10.1038/s41419-018-1081-0. (Co-corresponding)

5. Ho XB*, Pek MQN*, Soh BS.Disease modeling using 3D organoids derived from human induced pluripotent stem cells. Int J Mol Sci. 2018 Mar 21;19(4). pii: E936. doi: 10.3390/ijms19040936.

6. Ramanathan N, Tan HNE, Loh LJ, Soh BS, Yap WN.Tocotrienol is a cardioprotective agent against ageing-associated cardiovascular disease and its associated morbidities. Nutrition & Metabolism. 2018 15:6. doi: 10.1186/s12986-018-0244-4

7. Yang Y, Wu H, Kang X, Liang Y, Lan T, Li T, Tan T, Peng J, Zhang Q, An G, Liu Y, Yu Q, Ma Z, Lian Y, Soh BS, Chen Q, Liu P, Chen Y, Sun X, Li R, Zhen X, Liu P, Yu Y*, Li X*, Fan Y^*.Targeted elimination of mutant mitochondrial DNA in MELAS iPSCs by mito-TALENs. Protein Cell. 2018 Jan 9. doi: 10.1007/s13238-017-0499-y

8. Zheng D, Soh BS, Yin L, Hu G, Chen Q, Choi H, Han J, Chow VT, Chen J. Differentiation of Club Cells to Alveolar Epithelial Cells In Vitro. Sci Rep. 2017 Jan 27;7:41661.

9. Tan HN, Tay ZY, Soh BS. Intervention for cardiac review: A clinical perspective. Curr Stem Cell Res Ther. 2017 Jan 12.

10. Soh BS*, Ng SY*, Wu H, Buac K, Lian X, Xu J, Foo KS, He X, Nichane M, Yang H, Lei B, Li RA, Lim B, Chien KR. Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells (Nat. Commun. 2016 Mar 8;7:10774. doi: 10.1038/ncomms10774.) (*co-first author)

11. Ng SY*, Soh BS*, Rodriguez-Muela N, Hendrickson DG, Price F, Rinn JL, Rubin LL. Genome-wide RNA-seq of human motor neurons implicates selective ER stress activation in Spinal Muscular Atrophy. (Cell Stem Cell. 2015 Nov 5;17(5):569-84. doi: 10.1016/j.stem.2015.08.003. Epub 2015 Aug 27.) (*co-first author)

12. Soh BS*, Buac K*, Xu H*, Li E, Ng SY, Wu H, Chmielowiec J, Jiang X, Bu L, Li RA, Cowan C, Chien KR. N-cadherin prevents the premature differentiation of second heart field progenitors in the pharyngeal mesoderm microenvironment. Cell Res. 2014 Dec;24(12):1420-32. (Featured article) (*co-first author).

13. Tam WL, Lu H, Buikhuisen J, Soh BS, Lim E, Reinhardt F, Wu ZJ, Krall JA, Bierie B, Guo W, Chen X, Liu XS, Brown M, Lim B, Weinberg RA. Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells. Cancer Cell. 2013 Sep 9;24(3):347-64. doi: 10.1016/j.ccr.2013.08.005.

14. Ng SY, Bogu GK, Soh BS, Stanton LW.The long non-coding RNA RMST interacts with SOX2 to regulate neurogenesis. Mol. Cell. 2013 Aug 8;51(3):349-59.

15. Soh BS, Wu H, Chien KR. Cardiac regenerative medicine 2.0. Nat Biotechnol. 2013 Mar;31(3):209-11.

16. Soh BS*, Zheng D,  Yeo SL, Yang H, Ng SY, Wong LH, Zhang W, Li P, Nichane M, Asmat A, Wong PS, Wong PC, Su LL, Mantalaris A, Lu J, Xian W, McKeon F, Chen J, Lim EH* and Lim B*. CD166(pos) Subpopulation From Differentiated Human ES and iPS Cells Support Repair of Acute Lung Injury. Mol Ther. 2012 Dec;20(12):2335-46. (*Co-corresponding)

17. Zhang WC, Shyh-Chang N, Yang H, Rai A, Umashankar S, Ma S, Soh BS, Sun LL, Tai BC, Nga ME, Bhakoo KK, Jayapal SR, Nichane M, Yu Q, Ahmed DA, Tan C, Sing WP, Tam J, Thirugananam A, Noghabi MS, Huei Pang Y, Ang HS, Robson P, Kaldis P, Soo RA, Swarup S, Lim EH, Lim B.Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis. Cell. 2012 Jan 20;148(1-2):259-72.

18. Chia NY, Chan YS, Feng B, Lu X, Orlov YL, Moreau D, Kumar P, Yang L, Jiang J, Lau MS, Huss M, Soh BS, Kraus P, Li P, Lufkin T, Lim B, Clarke N, Bard F, Ng HH.  A genome-wide RNAi screen reveals determinants of human ES cell identity. Nature. 2010 Nov 11;468(7321):316-20.

19. Han J, Yuan P, Yang H, Zhang J, Soh BS, Li P, Lim SL, Cao S, Tay J, Orlov YL, Lufkin T, Ng HH, Tam WL, Lim B. Tbx3 improves the germ-line competency of induced pluripotent stem cells.

20. Soh BS, Song CM, Vallier L, Li P, Choong C, Yeo BH, Lim EH, Pedersen RA, Yang HH, Rao M, Lim B. Pleiotrophin enhances clonal growth and long-term expansion of human embryonic stem cells.