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Key Publications for Phospholipase A2

 

Monograph:

R. M. Kini (1997) Venom phospholipase A2 enzymes: structure, function and mechanism, John Wiley. All the experts in the field contributed to this monograph. This is regarded as one of the best books in the field. 

Reviews:

1. Kini, R. M.: Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes. Toxicon, 42, 827-840, 2003.

2. Kini, R.M.: Structure-function relationships and mechanism of anticoagulant phospholipase A2 enzymes from snake venoms. Toxicon, 45, 1147-1161, 2005.

3. Kini, R. M.: Anticoagulant proteins from snake venoms: Structure, function and mechanism. Biochem. J., 397, 377-387, 2006.

Book chapters:

1. Kini, R. M.: Phospholipase A2 - A complex multifunctional protein puzzle. In: Venom Phospholipase  A2 Enzymes: Structure, Function and Mechanism, Kini, R. M. (Ed) John Wiley, Chichester, England, pp. 1-28, 1997.

2. H. J. Evans and Kini, R. M.: Anticoagulant effects of phospholipases. In: Venom Phospholipase A2 Enzymes: Structure, Function and Mechanism, Kini, R. M. (Ed) John Wiley, Chichester, England, pp. 353-368, 1997.

3. Kini, R. M. and Evans, H. J.: Effects of phospholipase enzymes on platelet aggregation. In: Venom Phospholipase  A2 Enzymes: Structure, Function and Mechanism, Kini, R. M. (Ed) John Wiley, Chichester, England, pp. 369-387, 1997.

4. Kini, R. M.: Snake venom phospholipase  A2 enzymes in cell biology. In: Methods and Tools in Biosciences and Medicine: Animal Toxins. Rochat, H and Martin-Eauclaire, M. F. (Eds) Birkhauser, Verlag, Basel, Switzerland, pp. 304-318, 2000.

5. Doley, R., Zhou, X. D. and Kini, R. M.: Snake Venom Phospholipase  A2 Enzymes. In: Reptile Venoms and Toxins. Mackessy, S. P. (Ed) CRC Press/Taylor and Francis, in press, 2008.

Research papers:

1. Kini, R.M. and Iwanaga, S.: Structure ‑ function relationships of phospholipases I: Prediction of presynaptic neurotoxicity. Toxicon, 24, 527 ‑ 541, 1986.

2. Kini, R.M. and Iwanaga, S.: Structure ‑ function relationships of phospholipases II: Charge density distribution and the myotoxicity of presynaptically neurotoxic phospholipases. Toxicon, 24, 895 ‑ 905, 1986.

3. Kini, R.M. and Evans, H.J.: Structure ‑ function relationships of phospholipases: The anticoagulant region of phospholipases  A2. J. Biol. Chem., 262, 14402 ‑ 14407, 1987.

4. Vishwanath, B.S., Kini, R.M. and Gowda, T.V.: Characterization of three edema inducing phospholipase  A2 enzymes from habu (Trimeresurus flavoviridis) venom and their interaction with an alkaloid, aristolochic acid. Toxicon 25, 501 ‑ 515, 1987.

5. Kini, R.M. and Evans, H.J.: A model to explain the pharmacological effects of snake venom phospholipases  A2. Toxicon, 27, 613 ‑ 635, 1989.

6. Stefansson, S., Kini, R.M. and Evans, H.J.: The inhibition of clotting complexes of the extrinsic coagulation cascade by the phospholipase A2 isoenzymes from Naja nigricollis venom. Thrombos. Res., 55, 481 ‑ 491, 1989.

7. Stefansson, S., Kini, R.M. and Evans, H.J.: The basic phospholipase  A2 from Naja nigricollis venom inhibits the prothrombinase complex by a novel nonenzymatic mechanism. Biochemistry, 29, 7742-7746, 1990.

8. Kini, R. M. and Evans, H. J.: The role of enzymatic activity in inhibition of the extrinsic tenase complex by phospholipase  A2 isoenzymes from Naja nigricollis venom. Toxicon, 33, 1585-1590, 1995.

9. Huang, M. Z., Gopalakrishnakone, P. and Kini, R. M.: Antiplatelet effects of a phospholipase A(OHV A-PL A2) from the venom of Ophiophagus hannah (King cobra): role of platelet secretion. Life Sci., 61, 2211-2217, 1997.

10. Kini, R. M. and Chan, Y. M.: Accelerated evolution and molecular surface of venom phospholipase A2 enzymes. J. Mol. Evol. 48, 125-132, 1999.

11. Kerns, R. T., Kini, R. M., Stefansson, S. and Evans, H. J.: Targeting of venom phospholipases: the strongly anticoagulant phospholipase  A2 from Naja nigricollis venom binds to coagulation factor Xa to inhibit the prothrombinase complex. Arch. Biochem. Biophys. 369, 107-113, 1999.

12. Li, M., Fry, B. G. and Kini, R. M.: Putting the brakes on snake venom evolution: the unique molecular evolutionary patterns of Aipysurus eydouxii (Marbled sea snake) phospholipase  A2 toxins. Mol. Biol. Evol., 22, 934-941, 2005.

 

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