Research Areas
Protein chemistry, Structure-function relationships, Protein-protein interaction and Protein design and engineering.
Research Interests
The overall objective is to understand structure-function relationships of proteins, particularly snake venom toxins, and their mechanism. Snake venoms are rich sources of toxins that interfere with various physiological processes. We are specifically interested in protein families of phospholipase A2 (PLA2 ) enzymes, serine proteinases, three-finger toxins and helveprins. The functional diversity despite the structural similarity and the presence of functional sites in different segments of the toxins makes our research interesting and challenging. The functional sites are used in designing proteins with novel biological activities and prototypes of therapeutic agents.
Publications
Research Accomplishments
Toxins
from snake venoms
Toxins
from other venoms
Structure-function relationships of proteins (including
non-toxins)
Mechanism
of action
Protein
folding
Protein
design and engineering
Transcriptional control of protein expression
Evolution
of proteins
New
technologies
Other
Research Interests
Proteins in biomineralization
Proteins in angiogenesis
.gif){kind=spacer}
