Prof. Kini's Laboratory -
 
   

 

 

  Research

  People

  News

  Photos

  Links

  Contact

  Visitor's Comments


Sindhuja Sidharan

 

 

Veena S. Rao, PhD

 

 

 

 

 

Current institute: Thrombosis Research Institute, India

Jeremiah S. Joseph, PhD

 

Current institute: The SCRIPPS Reseach Institute, USA

Selvanayagam Nirthanan, PhD

 

Current institute: Griffith university, Australia

 

Rajamani Lakshminarayanan, PhD

 

Project: I studied the effect of proteins from egg shells on biomineralization.

Current Institute: Singapore Eye Research Institute, Singapore

 

 

Huang Minzhou, PhD

 

 

 

Current institute: University of Pennsylvania, USA

 

 

Gong Jianping, PhD

 

 

 

 

Zhang Wen Sheng, PhD

 

 

 

Pung Yuh Fen, PhD

 

Project: I have isolated two novel proteins from king cobra venom and deciphered their physiological role and mechanism.

Pawlak Joanna, PhD

 

Project: My project focussed on the structural and functional characterization of novel toxins - potential novel research tools and therapeutic agents.

Current institute: The SCRIPPS Reseach Institute, USA

 

Syed Rehana, PhD

 

Project: My research involved the purification and characterization of a novel protein from the venom of snakes.

Dileep Gangadharan N R A, PhD

 

 

Project: I studied the structure and structure-function relationships of two proteins from a novel family of snake venom proteins called waprins

 

 

Md Abu Reza, PhD

 

Project: I determined the structural differences of venom proteins with their counterpart in the plasma at cDNA level; Characterized the respective genes; Identified and characterized the promoters of the genes to understand their regulation of expression.

Current institute: Rajshahi University, Bangladesh

Kang Tse Siang, PhD

 

 

Project: α-conotoxins and χ /λ-conotoxins are short peptides with the same four conserved cysteines, but with distinct disulfide pairing (C1-3, C2-4 and C1-3, C2-4 respectively) resulting in globular and ribbon conformations. Through sequence alignment and subsequent studies using synthetic analogues, we have identified the importance of proline in the first intercysteine loop and C-terminal amide for the differential folding of these peptides. The folding propensities, as determined by coelution with regiospecifically synthesized conformers and NMR spectroscopy, indicate that these structural features act as conformations switches. Consequent conformation changes substantially impact the binding affinity of ImI conotoxin analogues to Aplysia Acetylcholine binding protein. The compact framework of these conotoxins present as attractive mini-protein scaffolds for presenting bioactive segments. As such, we have introduced RGD and KTS tripeptide sequences to design inhibitors of αIIbβ3 and α1β1 integrin receptors in this scaffold.

Current institute: The SCRIPPS Reseach Institute, USA

 

Yajnavalka Banerjee, PhD

 

Project: I studied the interaction between two anticoagulant three finger toxins that form a complex, isolated from the venom of snake, and using it as a model to gain an insight into the intricacies of protein-protein interaction using biophysical techniques such as CD, ITC, GEMMA and X-ray crystallography.

Teo Chung Pin - Graduate student

 

 

Project: My work involved the identification of binding partner for ohanin in the central nervous system.

Nandha Kishore, PhD

 

Project: I have isolated and characterized novel proteins from the venom of Ophiophagus hannah (King cobra).

Current institute: University of Heidelberg

Koh Cho Yeow, PhD

 

Project: My project involved the isolation and characterization of new anticoagulants from tick salivary gland extracts.

Angelina Tan Wei Ling


Project: Isolation and characterization of anticoagulant proteins from salivary gland extracts of ticks.This involves purification and structure-function studies of the novel proteins.

 

Ritu Chandna

 

Project: Characterization of novel three-finger toxins (3FTxs) identified from the snake Dysdalia coronoides venom gland.

 

.

 

Bidhan Nayak

 


 

Project: Sructure-activity relationship of a phospholipase A2 enzyme from S. violaceoruber, with the aim to design a small active scaffold of the enzyme.

Summer Han Xia

 

Project: Transcriptional regulation of Trocarin D from Tropidechis carinatus.

 

Varuna H.P.

 


Project: Structure-function relationships of a class of three-finger neurotoxins isolated from snake venom.

 

Iyer Janaki Krishnamoorthy

 



Project: Identification and characterization of anticoagulants from tick salivary gland extracts.

 

Norrapat Shih




Project: Pre-clinical studies of variegin, a very potent anticoagulant peptide isolated from the tick salivary gland.

   

             Lab Alumni

Last updated: