Research Areas
Protein
chemistry, Structure-function relationships, Protein-protein
interaction and Protein design and engineering.
Research
Interests
The
overall objective is to understand structure-function
relationships of proteins, particularly snake venom
toxins, and their mechanism. Snake venoms are rich sources
of toxins that interfere with various physiological
processes. We are specifically interested in protein
families of phospholipase A2 (PLA2 )
enzymes, serine proteinases, three-finger toxins and
helveprins. The functional diversity despite the structural
similarity and the presence of functional sites in different
segments of the toxins makes our research interesting
and challenging. The functional sites are used in designing
proteins with novel biological activities and prototypes
of therapeutic agents.
Publications
Research
Accomplishments
Toxins
from snake venoms
Toxins from other animals
Structure-function
relationships of proteins (including non-toxins)
Mechanism of action
Protein folding
Protein design
and engineering
Transcriptional control of protein expression
Evolution of proteins
New technologies
Other
Research Interests
Proteins
in biomineralization
Proteins
in angiogenesis
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