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Anticoagulant Effect of Naniproin

 

In continuation of our work on anticoagulant effects of three-finger toxins, we purified several others with different specificities towards blood coagulation proteases. Naniproin was purified from Naja nigricollis venom.  It is a monomer. Using ‘Dissection approach’ we showed that it specifically inhibits the prothrombinase complex.
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